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Updated: Jun 25, 2026

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
15:26

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

Published on: May 19, 2015

[Relationship between the grading of periventricular echodensities and periventricular white matter cystic lesions in

Wen-Juan Chen1, Yuan Hu, Hao-Rong Zhang

  • 1Division of B-Ultrasound, Hunan Children's Hospital, Changsha 410007, China. chenwjok@126.com

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|February 19, 2009
PubMed

Insights

The grading of periventricular echodensities (PVE) in preterm infants correlates with the risk and timing of white matter cystic lesions. Higher PVE grades indicate increased morbidity and earlier lesion development.

Area of Science:

  • Neonatal neurology
  • Pediatric imaging
  • Neurodevelopmental disorders

Background:

  • Periventricular echodensities (PVE) are common in preterm infants.
  • Understanding PVE grading's impact on white matter injury is crucial for prognostication.

Purpose of the Study:

  • To investigate the association between PVE grading and the morbidity and timing of periventricular white matter cystic lesions.
  • To determine if PVE severity predicts adverse outcomes in preterm neonates.

Main Methods:

  • Retrospective cohort study of 120 preterm infants diagnosed with PVE via ultrasonography.
  • Analysis of PVE grading (I, II, III) in relation to gestational age, birth weight, and cystic lesion development.

Main Results:

  • PVE grading correlated with birth weight but not gestational age.
  • Overall morbidity of cystic lesions was 24%.
  • PVE III showed significantly higher morbidity (65%) and earlier onset of cystic lesions compared to PVE II (21%).

Conclusions:

  • PVE grading is a significant predictor of periventricular white matter cystic lesion morbidity.
  • The severity of PVE influences the timing of cystic lesion occurrence in preterm infants.
Abstract

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