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Association between iron deficiency anemia and first febrile convulsion: A case-control study

Elham Bidabadi1, Mehryar Mashouf

  • 1Guilan University of Medical Sciences, No. 15, 135 ave., Golsar, Rasht 41658-55695, Iran. mashoof@mail.com

Seizure
|February 19, 2009
PubMed

Insights

This study found iron deficiency anemia is less common in children with febrile convulsions. Iron deficiency does not appear to protect against febrile seizures in children.

Area of Science:

  • Pediatrics
  • Hematology
  • Neurology

Background:

  • The link between iron deficiency anemia and febrile convulsions is debated, with conflicting research findings.
  • Iron status is a potential factor influencing the occurrence of febrile seizures in children.

Purpose of the Study:

  • To investigate the relationship between iron status and the incidence of a first febrile convulsion in children.
  • To clarify the role of iron deficiency in the development of febrile seizures.

Main Methods:

  • A case-control study involving 200 children aged 6 months to 5 years diagnosed with their first febrile convulsion.
  • A control group of febrile children without convulsions, matched for age and gender.
  • Assessment of iron status markers including serum iron, plasma ferritin, and total iron-binding capacity (TIBC).

Main Results:

  • Children with febrile convulsions showed higher levels of red blood cells (RBC), serum iron, and plasma ferritin, and lower TIBC compared to controls.
  • Iron deficiency anemia was less frequent in the febrile convulsion group, though not statistically significant.
  • The mean peak temperature was significantly higher in children experiencing febrile convulsions.

Conclusions:

  • Iron deficiency anemia appears less prevalent in children with febrile convulsions.
  • The study does not support a protective effect of iron deficiency against the development of febrile convulsions.
Abstract

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