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Related Concept Videos

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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RNA-seq

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Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...

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Related Experiment Video

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A Single-fly Assay for Foraging Behavior in Drosophila
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Published on: November 4, 2013

OnTheFly: a tool for automated document-based text annotation, data linking and network generation.

Georgios A Pavlopoulos1, Evangelos Pafilis, M Kuhn

  • 1Structural and Computational Biology Unit, EMBL Meyerhofstrasse 1, Heidelberg, . pavlopou@embl.de

Bioinformatics (Oxford, England)
|February 19, 2009
PubMed
Summary
This summary is machine-generated.

OnTheFly is a web tool that uses biological named entity recognition to enrich documents. It highlights genes, proteins, and chemicals, providing linked summaries and network visualizations for biological research.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Text Mining

Background:

  • Biological research generates vast amounts of unstructured text data.
  • Extracting and organizing information on biological entities (genes, proteins, chemicals) is crucial for scientific discovery.
  • Existing tools may lack integrated approaches for document enrichment and network analysis.

Purpose of the Study:

  • To introduce OnTheFly, a web-based application for biological named entity recognition.
  • To enhance scientific documents by identifying and annotating biological entities.
  • To facilitate the visualization of biological networks based on extracted entities.

Main Methods:

  • Web-based application utilizing biological named entity recognition.
  • Conversion of input documents (Office, PDF, plain text) to HTML.
  • Integration with the Reflect tagging server for entity highlighting and pop-up summaries.
  • Data retrieval from the STITCH database for network visualization.

Main Results:

  • OnTheFly successfully identifies and highlights biological entities within various document formats.
  • Pop-up windows provide comprehensive information, including descriptions, domain composition, and external links.
  • Graphical representations of biological association networks can be generated from extracted entities.

Conclusions:

  • OnTheFly offers a valuable tool for enriching scientific documents with biological information.
  • The application streamlines the process of accessing entity-specific data and understanding biological relationships.
  • OnTheFly supports researchers in navigating and analyzing complex biological information from textual sources.