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Related Experiment Video

Updated: Jun 25, 2026

Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer

Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer

Published on: June 13, 2019

Conserved gene expression programs integrate mammalian prostate development and tumorigenesis.

Colin Pritchard¹, Brig Mecham, Ruth Dumpit

¹Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.

Cancer Research

|February 19, 2009

Summary

Normal prostate development shares molecular pathways with prostate cancer. Key developmental gene expression programs, particularly during branching morphogenesis, are reactivated in prostate tumors, offering new insights into cancer phenotypes.

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Area of Science:

Developmental Biology
Cancer Biology
Molecular Oncology

Background:

Embryogenesis and carcinogenesis share signaling pathways.
Prostate development involves epithelium-stroma interactions.
Understanding normal development aids cancer research.

Purpose of the Study:

To determine molecular links between prostate development and carcinogenesis.
To characterize gene expression during murine prostate organogenesis.
To compare developmental gene expression with prostate cancer profiles.

Main Methods:

Gene expression profiling of murine prostate development stages (induction, branching morphogenesis, secretory differentiation).
Comparative analysis of gene expression in Pten and Myc-driven murine prostate cancers.
Validation of key developmental genes in human prostate cancer tissues.

Main Results:

A reproducible temporal gene expression program was identified during prostate organogenesis.
The gene expression profile of branching morphogenesis was significantly associated with both prostate cancer models.
Genes from the branching morphogenesis program (e.g., PRDX4, SLC43A1, DNMT3A) were altered in human prostate cancer.

Conclusions:

Normal prostate developmental processes are active in prostate neoplasia.
Developmental gene expression programs provide insights into prostate cancer phenotypes.
Exploiting organogenesis features can enhance understanding of cancer biology.