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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Long-term prognosis of diabetic patients with critical limb ischemia: a population-based cohort study

Ezio Faglia1, Giacomo Clerici, Jacques Clerissi

  • 1Diabetology Center, Diabetic Foot Center, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Multimedica, Sesto San Giovanni, Milano, Italy.

Diabetes Care
|February 19, 2009
PubMed

Insights

Diabetic patients with critical limb ischemia (CLI) face high risks of amputation and death. Early intervention and specialized care can significantly reduce these adverse outcomes, improving long-term prognosis.

Area of Science:

  • Vascular Surgery
  • Diabetology
  • Cardiology

Background:

  • Critical limb ischemia (CLI) poses a significant threat to diabetic patients.
  • Understanding the long-term prognosis is crucial for effective management.

Purpose of the Study:

  • To evaluate the long-term prognosis of critical limb ischemia (CLI) in diabetic patients.
  • To identify factors influencing mortality and amputation rates.

Main Methods:

  • A cohort of 564 diabetic patients hospitalized for CLI between 1999 and 2003 was followed for a mean of 5.93 years.
  • Peripheral angioplasty (PTA) and bypass graft (BPG) were performed as revascularization strategies.
  • Outcomes including major amputations, restenosis, bypass failures, and mortality were recorded.

Main Results:

  • Nearly 50% of patients died during the follow-up period.
  • Major amputation rates varied by treatment: 8.2% for PTA, 21.1% for BPG, and 59.2% for no revascularization.
  • Contralateral limb CLI occurred in 39.9% of patients, with 6.7% requiring major amputation.

Conclusions:

  • Diabetic patients with CLI have a high risk of amputation and mortality.
  • Coronary artery disease (CAD) is the leading cause of death.
  • Impaired ejection fraction is a major independent prognostic factor in patients with a history of CAD.
Abstract

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