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Related Experiment Video

Updated: Jun 25, 2026

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

Changes in experimental stroke outcome across the life span.

Fudong Liu¹, Rongwen Yuan, Sharon E Benashski

¹Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism

|February 19, 2009

Summary

Aging and sex significantly impact acute ischemic stroke outcomes. Stroke severity differs between sexes and changes with age, highlighting the need for age- and sex-specific stroke therapies in elderly patients.

Related Experiment Videos

Last Updated: Jun 25, 2026

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

Area of Science:

Neuroscience
Gerontology
Cardiovascular Research

Background:

Acute ischemic stroke is a major cause of death and disability, particularly in the elderly.
Age is a critical nonmodifiable risk factor for stroke.
Preclinical stroke research often overlooks the influence of aging and biologic sex.

Purpose of the Study:

To investigate how experimental stroke outcomes vary with aging and biologic sex.
To determine if observed sex differences in stroke are intrinsic or due to estrogen loss.
To inform the development of more relevant stroke therapies for the elderly population.

Main Methods:

Middle cerebral artery occlusion (MCAO) model in young and aging mice of both sexes.
Assessment of stroke outcomes, including infarct size and blood-brain barrier (BBB) permeability.
Ovariectomy was performed in young female mice to evaluate the role of estrogen.

Main Results:

Young female mice exhibited smaller strokes than males; ovariectomy reversed this effect.
Stroke damage increased with age in females but decreased in aging males.
Aging mice showed reduced edema formation, independent of sex and damage severity.
Cellular responses to stroke differed across the lifespan in both sexes.

Conclusions:

Aging and biologic sex significantly modulate acute ischemic stroke outcomes.
Estrogen plays a role in sex-based differences in stroke severity in younger animals.
Age-related changes in stroke response, including reduced edema, occur independently of sex.
Considering age- and sex-specific differences is crucial for developing effective stroke therapies for the elderly.