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5-HTTLPR genotype influences amygdala volume.

Harald Scherk1, Oliver Gruber, Patrick Menzel

  • 1AMEOS Klinikum Osnabrück, Knollstr. 31, 49088, Osnabrück, Germany. hsch.gf@osnabrueck.ameos.de

European Archives of Psychiatry and Clinical Neuroscience
|February 19, 2009
PubMed
Summary

The 5-HTTLPR gene polymorphism is linked to a larger right amygdala volume in individuals, regardless of bipolar disorder diagnosis. This suggests a potential role for this serotonin transporter gene in amygdala size.

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • The serotonin-transporter-linked polymorphic region (5-HTTLPR) genotype has been associated with amygdala activity in healthy individuals.
  • Previous research suggests a link between 5-HTTLPR and amygdala function, but its impact on amygdala volume requires further investigation.

Purpose of the Study:

  • To examine the effect of the 5-HTTLPR genotype on amygdala volume in bipolar disorder patients and healthy controls.
  • To determine if the influence of 5-HTTLPR on amygdala volume differs between diagnostic groups.

Main Methods:

  • Region of interest analysis of amygdala volume in 37 bipolar I disorder patients and 37 healthy controls.
  • Genotyping for the 5-HTTLPR polymorphism.
  • Statistical comparison between short allele carriers (SS/SL) and long allele carriers (LL).

Main Results:

  • Individuals carrying at least one short allele (SL or SS) of the 5-HTTLPR polymorphism showed a larger right amygdala volume compared to homozygous long allele carriers (LL).
  • This effect was observed irrespective of diagnostic status (bipolar disorder vs. healthy controls).
  • However, subsequent analyses incorporating diagnosis as a factor did not replicate these findings.

Conclusions:

  • The 5-HTTLPR polymorphism may influence amygdala size, potentially by affecting neuronal number or volume.
  • Further research is warranted to explore the relationship between serotonin transporter function, amygdala function, and volume.