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Published on: February 2, 2024
The core body temperature rhythm is altered in progressive supranuclear palsy
Keisuke Suzuki1, Tomoyuki Miyamoto, Masayuki Miyamoto
1Dept. of Neurology, Dokkyo Medical University, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi, Japan. keisuke@dokkyomed.ac.jp
Summary
Circadian rhythmicity in body temperature was reduced in patients with progressive supranuclear palsy compared to Parkinson disease patients, indicating altered thermoregulation.
Area of Science:
- Neuroscience
- Chronobiology
- Medical Research
Background:
- Circadian rhythmicity, the body's internal 24-hour clock, influences physiological processes like body temperature.
- Disruptions in circadian rhythms are implicated in various neurological disorders.
- Progressive supranuclear palsy (PSP) and Parkinson disease (PD) are neurodegenerative conditions with overlapping but distinct clinical features.
Purpose of the Study:
- To investigate and compare circadian rhythmicity in rectal temperature changes between patients with PSP and PD.
- To determine if differences in thermoregulation exist between these two neurodegenerative diseases.
Main Methods:
- Measurement of circadian rhythmicity in rectal temperature using data logging.
- Statistical analysis comparing the amplitude of body temperature fluctuations between patient groups.
Main Results:
- Patients with progressive supranuclear palsy exhibited a significantly reduced amplitude in their rectal temperature circadian rhythm.
- This reduction in temperature amplitude was more pronounced in PSP patients than in Parkinson disease patients.
Conclusions:
- Circadian thermoregulation is impaired in progressive supranuclear palsy.
- Reduced body temperature amplitude may serve as a potential biomarker differentiating PSP from Parkinson disease.
- Further research is warranted to explore the underlying mechanisms of altered thermoregulation in PSP.
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