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Updated: Jun 25, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
Aneuploidy in abortuses following IVF and ICSI
Vitaly A Kushnir1, John L Frattarelli
1New Jersey Medical School, UMDNJ, Dept. of Obstetrics, Gynecology and Women's Health, MSB E-506, 185 South Orange Avenue, Newark, NJ, 07101-1709, USA. vitalykushnir@yahoo.com
Purpose:
To compare aneuploidy rates in first trimester pregnancy losses following IVF+/-ICSI.
Methods:
A retrospective cohort analysis of karyotypes of abortuses following conventional IVF (n=159) and ICSI (n=196).
Results:
50.1% of losses were found to be cytogenetically abnormal among all patients undergoing IVF+/-ICSI. A significant increase in fetal aneuploidy rate was noted with increasing maternal age (<30 years=26.1% vs. 31 to 34 years.=38.2% vs. 35 to 39 years.=51.3% vs. >39 years.=65.9%). Aneuploidy rates were similar in the ICSI vs. conventional IVF groups (52.6% vs. 47.2% [p 0.31, RR 1.11, 95% CI 0.90, 1.38]). More sex chromosome anomalies were noted in the ICSI group.
Conclusions:
The aneuploidy rate in first trimester abortuses significantly increases with increasing maternal age. ICSI was not shown to significantly increase the aneuploidy rate. However, more sex chromosome anomalies were found among pregnancies resulting from ICSI.
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