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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: Jun 25, 2026

Isolating, Sequencing and Analyzing Extracellular MicroRNAs from Human Mesenchymal Stem Cells

Isolating, Sequencing and Analyzing Extracellular MicroRNAs from Human Mesenchymal Stem Cells

Published on: March 8, 2019

Genomic profiling of mesenchymal stem cells.

Danijela Menicanin¹, P Mark Bartold, Andrew C W Zannettino

¹Mesenchymal Stem Cell Group, Bone and Cancer Laboratories, Division of Haematology, Institute of Medical and Veterinary Science/ Hanson Institute and CSCR, University of Adelaide, SA, Australia.

Stem Cell Reviews and Reports

|February 19, 2009

Summary

Mesenchymal stem/stromal cells (MSC) gene expression profiling reveals key molecules for stem cell survival and growth. This knowledge aids in improving MSC-based tissue regeneration for clinical applications.

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Area of Science:

Stem Cell Biology
Genomics
Regenerative Medicine

Background:

Mesenchymal stem/stromal cells (MSC) are crucial for tissue regeneration due to their expansion potential.
Genomic profiling technologies like microarrays offer deep insights into MSC characteristics.

Purpose of the Study:

To review studies characterizing the gene expression profiles of MSCs.
To understand molecular mechanisms regulating MSC survival, growth, and differentiation.

Main Methods:

Review of existing literature on MSC genomic profiling.
Analysis of gene expression patterns from various MSC sources.

Main Results:

Genomic profiling enhances MSC characterization and biomarker identification.
Identified key molecules and signaling pathways governing MSC behavior.

Conclusions:

Understanding MSC gene expression improves strategies for tissue regeneration.
Genomic data is vital for advancing clinical applications of MSCs.