Related Experiment Video
Updated: Jun 25, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
[Testosterone metabolism and doping test results]
Łukasz Laczmański1, Marek Medraś
1Katedra i Klinika Endokrynologii, Diabetologii i Leczenia Izotopami, Akademia Medyczna im. Piastów Slaskich, Wrocław. laczman@endo.am.wroc.pl
Abstract:
Glucuronidation is one of the most important metabolic processes which eliminates androgens from the human organism. Three enzymes (UDP-glucuronosyltransferases) are responsible for transfering the glucuronic group from glucuronic acid to androgens: UGT2B7, UGT2B15 and UGT2B17. Glucuronide products are more polar, water soluble, less toxic and easily extracted form the body. Testosterone is a common androgen abused in sport. The norm for urinary testosterone/epitestosterone ratio is below 4.0. Large testosterone excretion is associated with a deletion polymorphism of the UGT2B17 gene. This polymorphism decreases T/E ratio level.
Related Concept Videos
Testosterone: Functions and Regulation
Drug Metabolism: Phase II Reactions
Serum Laboratory Studies, Stool Test, Breath Test
Drug Metabolism: Phase I Reactions