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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

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Updated: Jun 25, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

Statins, stem cells, and cancer.

Kalamegam Gauthaman1, Chui-Yee Fong, Ariff Bongso

  • 1Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Singapore.

Journal of Cellular Biochemistry
|February 19, 2009
PubMed
Summary
This summary is machine-generated.

Statins, known for lowering lipids and preventing heart disease, also exhibit anticancer properties. They inhibit cancer stem cell pathways, suggesting a dual role in preventing cardiovascular disease and certain cancers.

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Area of Science:

  • Biochemistry
  • Oncology
  • Stem Cell Biology

Background:

  • Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are established antilipid agents.
  • Emerging evidence highlights statins' anticancer effects via antiproliferation, apoptosis induction, and anti-angiogenesis.
  • These effects stem from the suppression of the mevalonate pathway, impacting cell cycle, signaling, and membrane integrity.

Purpose of the Study:

  • To review the relationship between statins, stem cells, and cancer.
  • To explore the potential of statins as anticancer agents targeting cancer stem cells.

Main Methods:

  • Review of recent scientific literature on statins, stem cells, and cancer.
  • Analysis of the mevalonate pathway's role in cell function and cancer stem cell properties.
  • Examination of human embryonic stem cells as a model for cancer stem cells.

Main Results:

  • Statins inhibit key cellular functions in cancer cells and human embryonic stem cells by suppressing the stemness pathway.
  • Shared genomic features exist between embryonic stem cells, cancer cells, and cancer stem cells, with overexpression of NANOG, OCT4, SOX2, and c-MYC in tumors.
  • Human embryonic stem cells serve as a valuable model for studying anticancer agents due to their similar properties to cancer and cancer stem cells.

Conclusions:

  • Statins demonstrate a dual role: lipid-lowering for cardiovascular health and anticancer effects by targeting cancer stem cells.
  • Targeting cancer stem cells with agents like statins, potentially combined with chemotherapy, represents a promising cancer treatment strategy.
  • Statins may offer a prophylactic benefit against certain cancers, in addition to their established role in cardiovascular disease prevention.