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Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise
Published on: February 20, 2017
Work of breathing during SIMV with and without pressure support
D-S Patel1, G F Rafferty, S Lee
1Division of Asthma, Allergy and Lung Biology, School of Medicine, King's College London, London, UK.
Archives of Disease in Childhood
|February 20, 2009
Summary
Adding pressure support to synchronised intermittent mandatory ventilation (SIMV) significantly reduces the work of breathing in infants. This method aids in weaning infants from mechanical ventilation, improving respiratory support outcomes.
Area of Science:
- Neonatal respiratory support
- Mechanical ventilation weaning strategies
Background:
- Mechanical ventilation is crucial for preterm infants.
- Weaning from mechanical ventilation requires careful management to minimize respiratory workload.
Purpose of the Study:
- To evaluate the impact of adding pressure support to SIMV on the work of breathing in infants.
- To test the hypothesis that pressure support reduces respiratory effort during mechanical ventilation weaning.
Main Methods:
- A prospective randomized trial involving 20 infants (mean gestational age 31 weeks) being weaned from mechanical ventilation.
- Interventions included 1-hour periods of SIMV alone versus SIMV with 50% pressure support.
- Work of breathing was quantified using the transdiaphragmatic pressure time product (PTPdi).
Main Results:
- SIMV with pressure support resulted in a mean PTPdi of 112 cm H(2)Oxs/min.
- This was approximately 20% lower than SIMV alone (141 cm H(2)Oxs/min), with statistical significance (p<0.001).
Conclusions:
- The addition of pressure support to SIMV effectively reduces the work of breathing in infants.
- This finding supports the use of pressure support as an adjunct to SIMV for ventilator weaning in neonates.
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