Related Experiment Video
Updated: Jun 25, 2026
Preservation of Porcine Donation after Circulatory Death (DCD) Liver by Perfusion and Orthotopic Liver Transplantation
Published on: June 14, 2024
Immunoprotection by polyethylene glycol in organ preservation solutions is not due to an immunomasking effect
Hélène Perrin1, Olivier Thaunat, Christophe Malcus
1INSERM, U851, 21 Avenue Tony Garnier, Lyon, F-69007, France. helene.perrin@inserm.fr
Background:
New organ preservation solutions that contain soluble polyethylene glycol (sPEG) molecules have been associated with reduction of acute rejection episodes.
Methods:
In the present manuscript we tested in vitro whether sPEG molecules were able to mask donor alloantigens and reduce graft immunogenicity.
Results:
Immunomasking effect was only evidenced when PEG molecules were covalently bound to donor cell surface.
Conclusion:
We concluded that sPEG in preservation solution are unlikely to display 'immunocamouflage' property.
