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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Detectability of glaucomatous changes using SAP, FDT, flicker perimetry, and OCT.

Hiroki Nomoto1, Chota Matsumoto, Sonoko Takada

  • 1Department of Ophthalmology, Kinki University School of Medicine, Osaka-Sayama City, Osaka, Japan. nomoto@ganka.med.kindai.ac.jp

Journal of Glaucoma
|February 20, 2009
PubMed
Summary

Frequency doubling technology (FDT), short-wavelength automated perimetry (SWAP), flicker perimetry, and optical coherence tomography (OCT) effectively detect early glaucoma. Retinal nerve fiber layer thickness (NFLT) via OCT shows the highest sensitivity for identifying glaucomatous changes in glaucoma suspects.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Diagnostic Technologies

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Early detection of glaucoma is crucial for timely intervention and vision preservation.
  • Current diagnostic methods include visual field testing and structural imaging.

Purpose of the Study:

  • To compare the diagnostic performance of various perimetric techniques and optical coherence tomography (OCT) in detecting early glaucoma.
  • To evaluate the detectability of glaucomatous visual field changes using standard automated perimetry (SAP), frequency doubling technology (FDT), short-wavelength automated perimetry (SWAP), and flicker perimetry.
  • To assess structural changes using OCT for glaucoma detection.

Main Methods:

  • The study included patients with open-angle glaucoma, glaucoma suspects (GSs), and healthy controls.
  • Visual field testing included SAP, SWAP, FDT (multiple test patterns), and flicker perimetry.
  • Structural assessment was performed using Stratus OCT, measuring retinal nerve fiber layer thickness (NFLT) and optic disc parameters.

Main Results:

  • All tested perimetric methods (FDT, SWAP, flicker) and OCT parameters demonstrated utility in differentiating healthy eyes from those with early glaucoma.
  • Flicker perimetry achieved the highest area under the curve (AUC) of 0.99 in the early glaucoma group.
  • Optical coherence tomography (OCT) parameters, particularly average retinal nerve fiber layer thickness (NFLT), showed high diagnostic accuracy (AUC >0.81), with NFLT achieving an AUC of 0.94 in glaucoma suspects.

Conclusions:

  • Frequency doubling technology (FDT), short-wavelength automated perimetry (SWAP), flicker perimetry, and optical coherence tomography (OCT) are valuable tools for diagnosing early glaucoma.
  • Retinal nerve fiber layer thickness (NFLT) measured by OCT exhibits the highest sensitivity for detecting early glaucomatous damage in glaucoma suspects.