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Updated: Jun 25, 2026
08:56
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
Relationship between circulating tumor necrosis factor system and bone mass before and after estrogen plus
Jung Gu Kim1, Seung-Yup Ku, Hoon Kim
1Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea. kimjg@plaza.snu.ac.kr
Menopause (New York, N.Y.)
|February 20, 2009
Summary
Lower tumor necrosis factor-beta (TNF-beta) levels in osteoporotic women increased after estrogen therapy, but the tumor necrosis factor (TNF) system did not predict bone mineral density (BMD) changes.
Area of Science:
- Endocrinology
- Bone Biology
- Immunology
Background:
- Estrogen plus progestogen therapy (EPT) is used to manage postmenopausal bone loss.
- The role of the tumor necrosis factor (TNF) system in bone metabolism and response to EPT is not fully understood.
Purpose of the Study:
- To investigate the relationship between the circulating TNF system and bone mineral density (BMD) before and after EPT in postmenopausal women.
Main Methods:
- Serum levels of TNF-alpha, TNF-beta, soluble TNF receptors (sTNFR1, sTNFR2), and bone turnover markers were measured.
- BMD at the lumbar spine and proximal femur were assessed.
- 70 out of 192 postmenopausal Korean women received sequential EPT for 1 year.
Main Results:
- Serum TNF-beta levels were lower in osteoporotic women than in normal women; TNF-alpha and sTNFR levels did not differ.
- After 6 months of EPT, serum TNF-beta levels increased significantly, while other TNF markers remained unchanged.
- Changes in BMD after 1 year of EPT were not correlated with baseline or 6-month TNF/sTNFR levels.
Conclusions:
- Serum TNF-beta is lower in osteoporotic postmenopausal women and increases with EPT.
- The circulating TNF system does not appear to predict BMD or bone response to EPT.
- The clinical utility of the TNF system for predicting BMD changes with EPT is limited.
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