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Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...

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Related Experiment Video

Updated: Jun 25, 2026

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

Phyllopod at the intersection of developmental signalling pathways.

Ben-Zion Shilo1

  • 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. benny.shilo@weizmann.ac.il

The EMBO Journal
|February 20, 2009
PubMed
Summary
This summary is machine-generated.

A small number of signaling pathways control development by interacting. Phyllopod, an EGFR target, uniquely regulates Notch and Wingless signaling in Drosophila eye development.

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Last Updated: Jun 25, 2026

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

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Published on: February 16, 2017

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Published on: December 14, 2015

Area of Science:

  • Developmental genetics
  • Cell signaling pathways
  • Gene expression regulation

Background:

  • Multicellular organism development relies on conserved signaling pathways.
  • These pathways transmit extracellular signals to modify gene expression.
  • Understanding pathway interactions is key to explaining developmental diversity.

Purpose of the Study:

  • To investigate the regulatory role of Phyllopod in Drosophila eye development.
  • To elucidate how Phyllopod interacts with other signaling pathways.

Main Methods:

  • Study of signaling pathways in Drosophila melanogaster.
  • Analysis of gene expression and developmental processes in the eye.

Main Results:

  • Phyllopod, a target of Epidermal Growth Factor Receptor (EGFR) signaling, exhibits a novel regulatory function.
  • Phyllopod influences the activity of Notch and Wingless signaling pathways.

Conclusions:

  • Conserved signaling pathways achieve developmental diversity through complex interactions.
  • Phyllopod plays a crucial role in integrating EGFR, Notch, and Wingless signaling in Drosophila eye development.