Bypass specialists operate together
Kei-ichi Takata1, Richard D Wood
1Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA.
The EMBO Journal
|February 20, 2009
Abstract:
New experiments show that different combinations of translesion DNA polymerases act to bypass lesions in mammalian cells, depending on the type of DNA damage. Bypass of most lesions tested was dependent on REV3L (pol zeta) and at least one additional DNA polymerase. The data fit a model whereby DNA polymerases work sequentially to bypass adducts in DNA.
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