Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Catenins01:23

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...
Structure of Cadherins01:25

Structure of Cadherins

The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This diversity of cadherins...
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...
Cytoskeletal Accessory Proteins01:13

Cytoskeletal Accessory Proteins

The cytoskeleton is an essential cell component that plays several structural and functional roles. However, the filaments that make up the cytoskeleton cannot function independently and depend on the accessory or ancillary proteins to effectively carry out their function. Accessory proteins associate with cytoskeletal filaments and their monomers, aiding filament formation and function. They also help in the cross-communication among cytoskeletal filaments. Cytoskeletal accessory proteins are...
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolutionarily old brainstem neurons are required for the control of selective spatial attention.

Nature communications·2026
Same author

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes.

Science (New York, N.Y.)·2026
Same author

Reliable Inference of the Encoding of Task States by Individual Neurons Using Calcium Imaging.

eNeuro·2026
Same author

An integrated transcriptomic and proteomic map of the mouse hippocampus at synaptic resolution.

Nature communications·2025
Same author

Cell type-specific in vivo proteomes with a multicopy mutant methionyl tRNA synthetase mouse line.

Lab animal·2025
Same author

Neuronal processes contain the essential components for the late steps of ribosome biogenesis.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same journal

Relationship between spontaneous EEG oscillations at 7 and 45 days of acute plateau exposure and the plateau acclimatization index.

Frontiers in neuroscience·2026
Same journal

Neuroprotective effects of paederoside against mitochondrial dysfunction in rotenone-induced cell models of Parkinson's disease.

Frontiers in neuroscience·2026
Same journal

Covariance-based analysis of spindle-band EEG during declarative and non-declarative odor cueing in sleep.

Frontiers in neuroscience·2026
Same journal

Correction: Physiological determinants of cortical P100 responses in pattern visual evoked potentials: a scoping review.

Frontiers in neuroscience·2026
Same journal

Transcranial magnetic stimulation and motor overflow: a systematic review in neurological disorders.

Frontiers in neuroscience·2026
Same journal

Editorial: Advancing neurodegenerative disease biomarkers: the role of neuroimaging in TDP-43 and tau proteinopathies.

Frontiers in neuroscience·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

Imaging Dendritic Spines in Caenorhabditis elegans
09:14

Imaging Dendritic Spines in Caenorhabditis elegans

Published on: September 27, 2021

N-cadherin, spine dynamics, and synaptic function.

Shreesh P Mysore1, Chin-Yin Tai, Erin M Schuman

  • 1Department of Neurobiology, Stanford University School of Medicine Stanford, CA, USA.

Frontiers in Neuroscience
|February 20, 2009
PubMed
Summary
This summary is machine-generated.

Disrupting N-cadherin, a key cell adhesion molecule, alters dendritic spine dynamics and synapse stability. This study reviews its structural, functional, and molecular impacts on synaptic plasticity.

Keywords:
N-cadherinhippocampusmeasurement noisespine dynamicsstructural constraints

More Related Videos

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

Related Experiment Videos

Last Updated: Jun 25, 2026

Imaging Dendritic Spines in Caenorhabditis elegans
09:14

Imaging Dendritic Spines in Caenorhabditis elegans

Published on: September 27, 2021

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

Area of Science:

  • Neuroscience
  • Cell Biology
  • Synaptic Plasticity

Background:

  • Dendritic spines form the postsynaptic side of excitatory synapses and are crucial for synaptic plasticity.
  • Spine dynamics, including changes in size and shape, are vital for learning and memory.
  • Synaptic stability, maintained by cell-adhesion molecules, ensures reliable communication.

Purpose of the Study:

  • To review the effects of disrupting N-cadherin on dendritic spine dynamics.
  • To highlight a novel method for detecting subtle changes in spine dynamics.
  • To model the consequences of N-cadherin disruption on synapses.

Main Methods:

  • Review of findings from Mysore et al. (2007).
  • Utilizing a novel method to detect fast and slow spine dynamics.
  • Analysis of structural, functional, and molecular data.

Main Results:

  • Acute N-cadherin disruption significantly impacts spine dynamics.
  • The study details structural, functional, and molecular consequences.
  • A working model is proposed linking acute to longer-term effects.

Conclusions:

  • N-cadherin plays a critical role in maintaining synaptic stability and regulating spine dynamics.
  • Disruption of N-cadherin has profound effects on synaptic structure and function.
  • Understanding these effects provides insights into synaptic plasticity mechanisms.