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Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

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Reduced skeletal muscle capillarization and glucose intolerance.

Steven J Prior¹, Michael J McKenzie, Lyndon J Joseph

¹Baltimore Geriatric Research, Education and Clinical Center, VA Maryland Health Care System, Baltimore, Maryland 21201, USA. sprior@grecc.umaryland.edu

Microcirculation (New York, N.Y. : 1994)

|February 20, 2009

Summary

Stroke survivors have reduced skeletal muscle capillarization, impacting glucose metabolism. This reduced blood vessel density in hemiparetic muscles is linked to glucose intolerance, highlighting potential benefits of interventions to improve muscle vascularization.

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Published on: May 16, 2021

Area of Science:

Exercise Physiology
Metabolic Health
Neurology

Background:

Reduced skeletal muscle capillarization in chronic stroke patients impairs nutrient and oxygen delivery.
This vascular deficit contributes to poor glucose metabolism and cardiovascular deconditioning.

Purpose of the Study:

To compare skeletal muscle capillarization between stroke survivors and sedentary controls.
To investigate the association between capillarization, glucose intolerance, and cardiorespiratory fitness (peak oxygen consumption) in stroke patients.

Main Methods:

Oral glucose tolerance tests, exercise tests, and vastus lateralis muscle biopsies were performed.
Twelve chronic stroke subjects and matched sedentary controls (impaired or normal glucose tolerance) participated.

Main Results:

Stroke subjects exhibited significantly lower capillarization in hemiparetic muscles compared to nonparetic muscles and controls with normal glucose tolerance.
Reduced capillary density in hemiparetic muscle was inversely correlated with glucose intolerance (120-minute glucose and glucose area under the curve).
Peak oxygen consumption was substantially lower in stroke subjects but did not correlate with capillarization.

Conclusions:

Skeletal muscle capillarization is reduced in the hemiparetic limb following stroke.
Lower capillarization is associated with impaired glucose metabolism in both stroke patients and controls.
Interventions aimed at enhancing skeletal muscle capillarization may improve glucose metabolism in chronic stroke survivors.