Confirmation of tonsillar anomalies in IgA nephropathy: a multicenter study

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M C Béné1, B Hurault De Ligny, M Kessler

  • 1Laboratoire d'Immunologie, Faculté de Médecine et CHU de Nancy, France.

Nephron
|January 1, 1991
PubMed

Tonsillar abnormalities have previously been evidenced in IgA nephropathy (IgAN). We report the results of a systematic quantitative analysis of 303 tonsils obtained in 70 IgAN patients and 142 controls. IgG- and IgA-producing plasma cells, stained by immunofluorescence, were enumerated on serial sections of all samples. Both the percentage and number of IgA+ cells were significantly increased in IgAN patients. This anomaly was also observed in age- or sex-matched subgroups of patients. Performed on a large series of individuals this study confirms the dysregulation of IgA production the upper respiratory tract of IgAN patients.

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