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Updated: Jun 25, 2026

Affinity Precipitation of Active Rho-GEFs Using a GST-tagged Mutant Rho Protein (GST-RhoA(G17A)) from Epithelial Cell Lysates
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Regulation of RhoGEF proteins by G12/13-coupled receptors.

Sandra Siehler1

  • 1Novartis Institutes for BioMedical Research Basel, Center for Proteomic Chemistry, Novartis Pharma AG, Basel, Switzerland. sandra.siehler@novartis.com

British Journal of Pharmacology
|February 20, 2009
PubMed
Summary

G protein-coupled receptors (GPCRs) signal through G proteins. This review focuses on G(12/13) pathways, highlighting RhoGEF proteins and their role in diseases like cancer and cardiovascular conditions.

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