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Synthesis and conformational analysis of cyclotetrapeptide mimetic beta-turn templates and validation as 3D scaffolds
Luca Gentilucci1, Giuliana Cardillo, Alessandra Tolomelli
1Department of Chemistry "G. Ciamician", University of Bologna, Italy. gentilucci@unibo.it
Chemmedchem
|February 20, 2009
Abstract:
The conformations of all stereoisomers of PMRI cyclotetrapeptide mimetics 1-8 are essentially determined by the predisposition of the diamine to stabilize beta-turns. The peptide mimetics can be regarded as 3D scaffolds for designing molecules with a predictable display of the pharmacophores. We used the models for testing novel RGD analogues as alpha(v)beta(3)-integrin receptor antagonists.
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