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Related Concept Videos

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

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Published on: February 7, 2021

Injectable microsphere/hydrogel combination systems for localized protein delivery.

Jangwook Lee1, Kuen Yong Lee

  • 1Department of Bioengineering, Hanyang University, Seoul 133-791, Republic of Korea.

Macromolecular Bioscience
|February 20, 2009
PubMed
Summary

Combining microspheres and hydrogels offers a novel injectable system for controlled protein release. This approach overcomes limitations of individual systems, enabling sustained therapeutic delivery.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Chemistry

Background:

  • Injectable delivery systems for therapeutic proteins are crucial for sustained treatment.
  • Hydrogels often exhibit rapid initial protein release, while microspheres face rapid clearance.
  • Existing systems have limitations in achieving prolonged and controlled protein delivery.

Purpose of the Study:

  • To develop and evaluate a combined microsphere/hydrogel system for controlled and sustained injectable protein delivery.
  • To investigate the potential of this hybrid system to overcome the limitations of individual hydrogel and microsphere formulations.
  • To establish the primary parameters controlling protein release from the combined system.

Main Methods:

  • Poly(lactic-co-glycolic acid) (PLGA) microspheres encapsulating a model protein were prepared.
  • These microspheres were mixed with alginate gels to form a composite injectable system.
  • Protein release profiles were analyzed based on varying ratios of microspheres to hydrogel components.

Main Results:

  • The combined microsphere/hydrogel system demonstrated modulated protein release kinetics.
  • The ratio of microspheres to alginate gel was identified as the key factor governing protein release rates.
  • This hybrid formulation showed potential for sustained release over extended periods.

Conclusions:

  • Microsphere/hydrogel combination systems represent a promising strategy for injectable, localized protein delivery.
  • This approach offers enhanced control over release kinetics compared to standalone hydrogels or microspheres.
  • The developed system has potential applications in developing advanced localized drug delivery solutions.