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Exploration of cytotoxic effect of malathion on some rat organs structure
L Saadi1, N Lebaili, M Benyoussi
1Département de Biologie, Faculté des Sciences Agro-Vétérinaires Université Saad Dahleb de Blida, Algérie.
Abstract:
Widespread use of insecticides has caused several risks to public health. This work was designed to investigate the histological changes in Liver, lung, adrenal medulla and testis of Wistar rats treated with malathion, administered intra peritoneally at a dose of 33,051 mg/kg per day. Exposure to the malathion, for 40 days, induced histological alterations: regular arrangement of hepatocytes with dilated sinusoidal spaces, thickened Lung epithelium, regression of adrenal medulla with congestion and disruption of the germ Line. These alterations represent the signs of cytotoxicity of malathion in Wistar rats.
Insights
Malathion insecticide exposure caused liver, lung, adrenal, and testis damage in rats. These histological changes indicate malathion
Area of Science:
- Toxicology
- Histopathology
- Environmental Health
Background:
- Insecticides like malathion are widely used in agriculture and public health.
- Pesticide exposure poses significant risks to human and animal health.
- Understanding organ-specific toxicity is crucial for risk assessment.
Purpose of the Study:
- To investigate the histological effects of malathion on key organs in Wistar rats.
- To identify specific cytotoxic alterations induced by malathion exposure.
- To assess the impact of malathion on liver, lung, adrenal medulla, and testis tissues.
Main Methods:
- Wistar rats were administered malathion intraperitoneally at a dose of 33,051 mg/kg/day.
- Exposure duration was 40 days.
- Histological examination of liver, lung, adrenal medulla, and testis tissues was performed.
Main Results:
- Malathion exposure led to dilated sinusoidal spaces in the liver.
- Thickened lung epithelium was observed.
- Adrenal medulla showed regression and congestion.
- Disruption of the germline in the testis was evident.
Conclusions:
- Malathion induces significant histological alterations across multiple organs in Wistar rats.
- Observed changes, including hepatocyte and germline disruption, signify malathion's cytotoxicity.
- These findings highlight the potential health risks associated with malathion exposure.
