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Multiple growths of primary calvarial meningiomas
1Department of Neurological Surgery, Hidaka General Hospital, Gobo City, Wakayama, Japan.
Abstract:
The authors present the case of a 68-year-old woman with multiple growths of primary calvarial meningiomas. Histological examination revealed one tumor arising in the left parietal bone that showed some malignant aspects, including hypercellularity, cellular pleomorphism, necrotic foci, and some mitoses; the tumor partially had a meningotheliomatous pattern. Two other tumors in the right parietal bone were meningotheliomatous meningiomas without any malignant features. With a review of the literature, the pathogenesis of the multiplicity is discussed.
Insights
This study reports a rare case of multiple primary calvarial meningiomas in a 68-year-old woman. One tumor exhibited malignant features, while others were benign, prompting a discussion on the pathogenesis of multiple meningiomas.
Area of Science:
- Neurosurgery
- Oncology
- Pathology
Background:
- Meningiomas are tumors arising from the meninges.
- Primary calvarial meningiomas are rare, and multiple occurrences are even rarer.
Observation:
- A 68-year-old woman presented with multiple primary calvarial meningiomas.
- Histological analysis revealed one left parietal tumor with malignant characteristics (hypercellularity, pleomorphism, necrosis, mitoses) and a meningotheliomatous pattern.
- Two right parietal tumors were identified as benign meningotheliomatous meningiomas.
Findings:
- The case highlights the potential for malignant transformation within multiple primary calvarial meningiomas.
- Differential diagnosis and histological features distinguishing benign from malignant meningiomas are crucial.
Implications:
- Understanding the pathogenesis of multiple meningiomas is essential for diagnosis and treatment.
- This case contributes to the literature on rare cranial tumors and their varied histological presentations.