[Lipidspectrum dynamics in patients with myocardial infarction undergoing hypoxic therapy in a pressure chamber]

The aim of the study was to evaluate effect of adaptation to periodic hypoxia in pressure chamber (PHPC) on the serum lipid profile in 45 patients with myocardial infarction (MI) in the period of scarring compared with physical exercises (15 patients). Adaptive therapy was shown to cause significant decrease of total cholesterol, LDLP, triglicerides, and atherogenic index. A course of PHPC resulted in a significant 6.6% fall of serum apoA1 (major component of HDLP). Examination of the serum lipid profile in control patients with MI demonstrated a 4% decrease of the ApoA1/ApoB ratio compared with its value in the PHPC group despite positive dynamics of the parameters of cholesterol metabolism being measured. Taken together, these data suggest the lack of positive changes at the level of major pathways of cholesterol metabolism.