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HLA types in Turkish children with celiac disease

Zarife Kuloğlu1, Tümay Doğanci, Aydan Kansu

  • 1Department of Pediatric Gastroenterology, Ankara University Faculty of Medicine, Ankara, Turkey.

The Turkish Journal of Pediatrics
|February 21, 2009
PubMed

Insights

This study found specific human leukocyte antigen (HLA) types are more common in Turkish children with celiac disease (CD). Certain HLA variants correlate with classical versus atypical CD presentations, suggesting a genotype-phenotype link.

Area of Science:

  • Immunogenetics
  • Pediatric Gastroenterology

Background:

  • Celiac disease (CD) is an autoimmune disorder influenced by genetic factors.
  • Human leukocyte antigen (HLA) genes play a critical role in immune responses and are strongly associated with CD susceptibility.
  • Understanding HLA distribution in specific populations like Turkish children with CD is crucial for diagnosis and management.

Purpose of the Study:

  • To determine the frequency of HLA antigen groups in Turkish children diagnosed with celiac disease.
  • To investigate the association between specific HLA types and the clinical manifestations of celiac disease in this pediatric cohort.
  • To explore potential correlations between HLA genotype and disease presentation in Turkish children with CD.

Main Methods:

  • Serological HLA typing using standard lymphocytotoxicity techniques was performed.
  • A cohort of 75 Turkish children with celiac disease (45 classical, 30 atypical) was studied.
  • A control group of 100 healthy renal transplantation donors was included for comparison.

Main Results:

  • Frequencies of HLA B13, CW7, B8, DR7, DR17, and DQ2 were significantly higher in celiac disease patients compared to controls.
  • HLA DQ2, B8, DR17, and B13 showed significantly elevated relative risks for celiac disease.
  • Distinct HLA associations were observed between classical and atypical celiac disease, with HLA B35, DR11, and DQ7 more frequent in classical CD, and HLA B8 associated with atypical CD.

Conclusions:

  • Specific HLA alleles are significantly associated with celiac disease in Turkish children.
  • Certain HLA types correlate with different clinical presentations of celiac disease, indicating a potential genotype-phenotype relationship.
  • Further research may elucidate the precise role of HLA in celiac disease pathogenesis and clinical variability.

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