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Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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Ankle Joint01:10

Ankle Joint

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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Related Experiment Video

Updated: Jun 25, 2026

Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography
06:31

Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography

Published on: October 6, 2023

Jaccoud's arthropathy revisited.

David Martínez1

  • 1Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico. damartinez@rcm.upr.edu

Boletin De La Asociacion Medica De Puerto Rico
|February 21, 2009
PubMed
Summary

Jaccoud's arthropathy, a rare condition causing hand deformities, can mimic rheumatoid arthritis. This case highlights its association with systemic lupus erythematosus (SLE) and the need for careful joint examination.

Area of Science:

  • Rheumatology
  • Clinical Medicine

Background:

  • Jaccoud's arthropathy is a chronic, non-erosive, rheumatoid-like hand deformity linked to rheumatic fever and systemic lupus erythematosus (SLE).
  • Differentiating Jaccoud's arthropathy from rheumatoid arthritis (RA) can be challenging due to overlapping clinical features, particularly hand deformities.

Observation:

  • A 43-year-old woman initially diagnosed with Sjögren's syndrome and RA presented with reducible hand deformities.
  • Radiographic evaluation revealed no joint destruction, indicating the deformities were inconsistent with typical RA.

Findings:

  • The patient's presentation and reducible hand deformities without joint destruction were characteristic of Jaccoud's arthropathy.
  • The arthropathy was ultimately associated with a later diagnosis of SLE, underscoring the connection between these conditions.

Related Experiment Videos

Last Updated: Jun 25, 2026

Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography
06:31

Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography

Published on: October 6, 2023

Implications:

  • This case emphasizes the critical importance of meticulous joint examination in diagnosing rheumatic diseases.
  • Recognizing Jaccoud's arthropathy is crucial for accurate SLE diagnosis and management, distinguishing it from RA.