Related Experiment Video
Updated: Jun 25, 2026
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
[Protocol with GnRH-antagonist and ovulation trigger with GnRH-agonist in risk patients--a reliable method of
Unlabelled:
OHSS is a serious complication of COH and PCOS is a major risk factor for its development.
Objective:
The objective of this study is to evaluate the effect of the application of GnRH-agonist in patients with PCOS for triggering the ovulation and prophylactic of OHSS.
Materials And Methods:
In the present study we evaluated 29 patients with PCOS who had been stimulated for the purposes of ART with gonadotrophins and GnRH-antagonist and application of GnRH-agonist (Decapeptyl; Dipherilyn-0.2 mg) instead of HCG.
Results:
From the observed group one patient developed severe form of late OHSS. The average number of aspirated oocytes was 22.5 and the clinical pregnancy was 46.8%.
Conclusion:
The application of protocole with GnRH-antagonist and triggering of the ovulation with GnRH-agonist is a good alternative when a high risk of development of OHSS exists and our results prove that.
Related Concept Videos
01:30Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
01:27Ovarian Cycle
01:22Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.