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Sudomotor function in autonomic failure.

S M Baser1, J Meer, R J Polinsky

  • 1Clinical Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.

Neurology
|October 1, 1991
PubMed
Summary
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Patients with autonomic failure produced less sweat, indicating impaired sweat gland function. This study suggests human sweat glands do not develop chronic denervation supersensitivity, with intradermal methacholine effectively assessing gland function.

Area of Science:

  • Autonomic Nervous System Research
  • Human Physiology
  • Neurology

Background:

  • Autonomic failure involves dysfunction of the autonomic nervous system.
  • Sweat production is a key indicator of sympathetic nervous system function.
  • Understanding sweat gland response is crucial for diagnosing autonomic disorders.

Purpose of the Study:

  • To measure sweat production via direct gland stimulation in patients with autonomic failure.
  • To assess the sympathetic skin response (SSR) in relation to sweat production.
  • To investigate sweat gland function and denervation supersensitivity in autonomic failure.

Main Methods:

  • Direct sweat gland stimulation using intradermal methacholine.
  • Assessment of sympathetic skin response (SSR) to electrical stimulation.

Related Experiment Videos

  • Comparison of sweat production in patients with pure autonomic failure (PAF) and multiple system atrophy (MSA) against normal subjects.

    • Main Results:

    • Patients with PAF and MSA showed significantly reduced sweat production compared to controls.
    • No patients exhibited abnormally high sweat production.
    • The SSR did not correlate with methacholine-induced sweat response, indicating SSR can exist without normal sweat function.

    Conclusions:

    • Impaired sweat gland function does not distinguish between MSA and PAF.
    • Diminished sweat response suggests human sweat glands do not develop chronic denervation supersensitivity.
    • Intradermal methacholine provides a straightforward method for evaluating sweat gland function.