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Updated: Jun 25, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Necessary but not sufficient: a comparison of surveillance definitions of Clostridium difficile-associated diarrhea
Thomas G Fraser1, Cynthia Fatica, Steven M Gordon
1Cleveland Clinic, Department of Infectious Disease, Cleveland, Ohio 44195, USA. frasert@ccf.org
Abstract:
In this article, we describe our comparison of the Cleveland Clinic surveillance definition of Clostridium difficile-associated diarrhea and the definition mandated by the Ohio Department of Health. We found the definitions to be concordant only 71% of the time; the Ohio Department of Health definition identified 278 of the 391 cases identified by the Cleveland Clinic definition. Surveillance definitions mandated by the Ohio Department of Health overrepresented the number of cases attributable to nosocomial transmission at our institution.
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