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Moderate alcohol consumption is associated with better endothelial function: a cross sectional study.
Keiko Suzuki1, Mitchell S V Elkind, Bernadette Boden-Albala
1Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY, USA. majokko7174@gmail.com
BMC Cardiovascular Disorders
|February 21, 2009
Summary
Moderate alcohol consumption, up to two drinks daily, is linked to improved endothelial function (FMD) in a multiethnic population. This finding may explain alcohol
Area of Science:
- Cardiovascular Science
- Vascular Biology
- Nutritional Epidemiology
Background:
- Moderate alcohol consumption is associated with reduced coronary artery disease risk.
- Endothelial dysfunction is a key factor in atherosclerosis and cardiovascular disease.
- Few studies have investigated alcohol's impact on endothelial function, specifically brachial artery flow-mediated dilation (FMD).
Purpose of the Study:
- To examine the association between lifetime alcohol intake and brachial artery flow-mediated dilation (FMD).
- To determine if moderate alcohol consumption is linked to improved endothelial function.
Main Methods:
- Cross-sectional analysis of 884 participants in the Northern Manhattan Study (NOMAS).
- Assessed lifetime alcohol intake and brachial artery FMD using high-resolution ultrasound.
- Adjusted for traditional cardiovascular risk factors in multivariate analysis.
Main Results:
- Moderate alcohol consumption (up to 2 drinks/day) was associated with a higher likelihood of FMD above the median.
- This association remained significant after adjusting for multiple cardiovascular risk factors (adjusted OR 1.8, p=0.03).
- No significant benefit on FMD was observed for consumption exceeding 2 drinks/day.
Conclusions:
- Consumption of up to 2 alcoholic beverages per day is independently associated with better FMD in a multiethnic population.
- Improved FMD may be a mechanism underlying the cardioprotective effects of moderate alcohol intake.
- Findings suggest a potential link between moderate alcohol use and vascular health.
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