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Updated: Jun 25, 2026
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Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
Published on: November 19, 2014
[Psychopathologic and cognitive investigations in schizophrenia]
1Semmelweis Egyetem Mentális Egészségtudományok Doktori Iskola Budapest Balassa u. 6. 1083. farkas@psych.sote.hu
Orvosi Hetilap
|February 21, 2009
Summary
Schizophrenia patients experience persistent positive symptoms, with hallucinations worsening over time. Cognitive deficits in associative learning distinguish schizophrenia subtypes, impacting treatment strategies.
Area of Science:
- Psychiatry and Psychology
- Neuroscience
Context:
- Long-term course of psychotic disorders, specifically schizophrenia.
- Cognitive functions in schizophrenia patients.
Purpose:
- To analyze the long-term progression of delusions and hallucinations in schizophrenia.
- To investigate feedback-guided associative learning and acquired equivalence in schizophrenia patients and controls.
- To differentiate schizophrenia subtypes based on cognitive and symptomatic profiles.
Summary:
- Positive symptoms like delusions and hallucinations persist in schizophrenia, with hallucinations showing a significant worsening after 5 years.
- Feedback-guided associative learning is impaired in deficit schizophrenia subtypes, while acquired equivalence is impaired in both deficit and non-deficit subtypes.
- Cognitive deficits in associative learning can distinguish schizophrenia subtypes, independent of frontal lobe test performance.
Impact:
- Provides insights into the long-term trajectory of positive symptoms in schizophrenia.
- Highlights the role of specific cognitive deficits in differentiating schizophrenia subtypes.
- Informs potential therapeutic targets for cognitive remediation in schizophrenia.
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