Related Experiment Video
Updated: Jun 25, 2026

Super-Resolution Microscopy of the Synaptonemal Complex Within the Caenorhabditis elegans Germline
Published on: September 13, 2022
Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution
Björn Nilsson1, Mikael Johansson, Fatima Al-Shahrour
1Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA. bnilsson@broad.mit.edu
Motivation:
Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size.
Results:
We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy.
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