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Updated: Jun 25, 2026

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
Published on: October 17, 2017
Monocytes in acute coronary syndromes.
Eduard Shantsila1, Gregory Y H Lip
1Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, England, UK.
Monocytes play a key role in acute coronary syndromes, influencing disease progression and recovery. This overview examines their involvement in inflammation, clotting, and restoring blood flow through angiogenesis.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Pathophysiology
Background:
- Acute coronary syndromes (ACS) involve complex inflammatory and thrombotic processes.
- Monocytes are critical immune cells implicated in cardiovascular disease pathogenesis.
Purpose of the Study:
- To review the multifaceted roles of monocytes in ACS.
- To explore monocyte contributions to pathological processes and healing.
Main Methods:
- Literature review of studies on monocyte function in ACS.
- Analysis of data on monocyte involvement in inflammation, coagulation, and angiogenesis.
Main Results:
- Monocytes contribute to plaque instability and thrombus formation in ACS.
- They are involved in the resolution of inflammation and tissue repair post-ACS.
- Monocyte-derived factors promote angiogenesis, aiding microcirculation restoration.
Conclusions:
- Monocytes are central players in both the development and resolution phases of ACS.
- Targeting monocyte pathways may offer therapeutic strategies for ACS management and recovery.
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