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Published on: February 14, 2017
Effects of artificial colloids on haemostasis
1Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
British Journal of Hospital Medicine (London, England : 2005)
|February 21, 2009
Summary
Artificial colloids, used to manage bleeding in trauma and surgery, are more effective than crystalloids but can disrupt normal blood clotting. Understanding these effects is crucial for patient safety.
Area of Science:
- Biomedical science
- Pharmacology
- Critical care medicine
Background:
- Artificial colloids are frequently administered to patients experiencing significant blood loss, such as those with trauma or undergoing surgery.
- While colloids demonstrate greater efficacy in fluid resuscitation compared to crystalloids, their use is not without potential complications.
Purpose of the Study:
- To review the mechanisms by which artificial colloids can negatively impact the haemostatic system.
- To highlight the potential for colloids to interfere with normal blood clotting processes.
Main Methods:
- Literature review of existing studies on artificial colloids and haemostasis.
- Analysis of the biochemical and physiological interactions between colloids and coagulation factors.
- Examination of clinical data associating colloid administration with bleeding complications.
Main Results:
- Colloids can lead to dilution of coagulation factors and impaired platelet function.
- Specific colloid formulations may have varying effects on different components of the haemostatic cascade.
- Evidence suggests a link between colloid use and increased risk of bleeding or coagulopathy.
Conclusions:
- Artificial colloids, despite their benefits in volume expansion, pose a risk of haemostatic derangement.
- Further research is needed to elucidate the precise mechanisms and to develop safer colloid alternatives or management strategies.
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