The bright side of the glial scar in CNS repair
Asya Rolls1, Ravid Shechter, Michal Schwartz
1Asya Rolls, Ravid Shechter and Michal Schwartz are at the Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel.
Abstract:
Following CNS injury, in an apparently counterintuitive response, scar tissue formation inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar-modulating treatments have become a leading therapeutic goal in the field of spinal cord injury. However, increasing evidence suggests a beneficial role for this scar tissue as part of the endogenous local immune regulation and repair process. How can these opposing effects be reconciled? Perhaps it is all a matter of timing.
More Related Videos
Related Concept Videos
Neurogenesis and Regeneration of Nervous Tissue
Glial Cells
Nervous Tissue: Glial Cells
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...


