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Tumor necrosis factor-beta specifically inhibits the activity of preoptic warm-sensitive neurons in tissue slices
T Nakashima1, T Kiyohara, T Hori
1Department of Physiology, Saga Medical School, Japan.
Neuroscience Letters
|July 8, 1991
Abstract:
Effects of human tumor necrosis factor-beta (TNF-beta) were studied on the single neural activities of the preoptic thermosensitive and thermally insensitive neurons in tissue slices of rats. Physiological doses (0.7-40 ng/ml) of TNF-beta decreased the firing rate in most of the warm-sensitive neurons, but showed no marked tendency in the response patterns of thermally insensitive neurons. The actions of TNF-beta on warm-sensitive neurons were blocked by concurrent application of sodium salicylate. The results suggest that the intracranial TNF may produce fever through local production of prostaglandins.