Related Experiment Video
Updated: Jun 25, 2026

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
Published on: December 1, 2023
Possible role of receptor heteromers in multiple sclerosis
A O Tarakanov1, K G Fuxe, L F Agnati
1St. Petersburg Institute for Informatics and Automation, Russian Academy of Sciences, St. Petersburg, Russia. tar@iias.spb.su
Abstract:
Recent results suggest that cytokine and glutamate receptors can interact directly and form receptor heteromers. Due to such heteromers, cytokines can act not only as classical neuromediators but also directly enhance glutamate gated ion channel activity via allosteric mechanisms. Our opinion is that such heteromers may lead to enhanced glutamate neurotoxicity in pathogenic processes of multiple sclerosis. Thus, agents targeting evolutionary conserved leucine-rich motifs responsible for such dimerization of receptors may represent a useful strategy to inhibit excitotoxicity in multiple sclerosis.
Related Concept Videos
Multiple Sclerosis l: Introduction
The Two-State Receptor Model
The binding affinity of a drug determines its interaction with one...
Diversity of Antigen Receptors
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Spare Receptors

