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Antagomirzymes: oligonucleotide enzymes that specifically silence microRNA function
Vaibhav M Jadhav1, Vinod Scaria, Souvik Maiti
1Institute for Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110 007, India.
Angewandte Chemie (International Ed. in English)
|February 21, 2009
Abstract:
Many important cellular processes are regulated by small endogenous noncoding RNAs known as microRNAs (miRNAs). The precise molecular function of many miRNAs is unknown; different loss-of-function methods are required to gain insight into the biology of these small RNA molecules. Nucleic acid enzymes termed antagomirzymes are now shown to be valuable tools for the specific knockdown of miRNA in vitro and in vivo (see scheme).
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