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Updated: Jun 25, 2026

Characterization of Neuromuscular Junctions in Mice by Combined Confocal and Super-Resolution Microscopy
Published on: December 8, 2021
Adult nemaline myopathy with trabecular muscle fibers
Viktoriya S Irodenko1, Han S Lee, Stephen J de Armond
1Department of Neurology, University of California, School of Medicine, 505 Parnassus Avenue, / San Francisco, California 94143-0114, USA. viktoriya.irodenko@ucsf.edu
Abstract:
The term "trabecular myopathy" has been used to designate a syndrome resembling limb-girdle muscular dystrophy in which the predominant pathological feature is an abundance of lobulated or trabecular muscle fibers. However, the validity of this nosological entity has not been verified. Herein we describe a 63-year-old man with a severe, progressive myopathy who exhibited the typical pathological features of both trabecular myopathy and nemaline myopathy in association with a biclonal gammopathy. In this case, adult-onset nemaline myopathy was probably the primary disease process. The diagnostic significance of trabecular muscle fibers remains uncertain.
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