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Updated: Jun 25, 2026
07:45
An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
Published on: October 21, 2014
Gliogenesis: historical perspectives, 1839-1985.
Henry deF Webster1, Karl E Aström
1Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke MSC, Bethesda, MD 20892-1400, USA. websterh@ninds.nih.gov
Advances in Anatomy, Embryology, and Cell Biology
|February 24, 2009
Summary
This review traces the historical discovery of glial cells, from early concepts of "Nervenkitte" to modern understanding of glial cell types and development in the nervous system.
Area of Science:
- Neuroscience
- Cell Biology
- Developmental Biology
Background:
- The concept of glia evolved from Virchow's "Nervenkitte" (glue) to understanding distinct cell types.
- Early studies faced limitations due to microscopy and staining techniques.
Observation:
- Microscopic advancements and metallic impregnation methods revealed glia as distinct cells, not a ground substance.
- Light microscopy identified astroglia, oligodendroglia, microglia, ependymal cells (CNS), and Schwann cells (PNS).
Findings:
- Subsequent research characterized the origins, development, morphology, and differentiation of various glial cell types.
- Electron microscopy, immunostaining, and in vitro models significantly expanded knowledge of glial cell behavior.
- By 1985, substantial progress was made in understanding glial cell origins, development, and functions.
Implications:
- Understanding glial cell development is crucial for comprehending nervous system structure and function.
- Advances in methodology have been key to unraveling the complexities of gliogenesis.
- Continued research into glial cells promises further insights into neurological processes and diseases.
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