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Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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The ABO Blood Group

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Updated: Jun 25, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Transfusion medicine and safety.

Roger Dodd¹, W Kurt Roth, Paul Ashford

¹American Red Cross Holland Laboratory, 15601 Crabbs Branch Way, Rockville, MD 20855, USA. dodd@usa.redcross.org

Biologicals : Journal of the International Association of Biological Standardization

|February 24, 2009

Summary

Blood transfusion safety has advanced through screening for infections like HBV, HCV, and HIV using immunoassays and nucleic acid tests (NAT). Current efforts focus on bacterial contamination and pathogen inactivation to ensure the safest blood supply.

Related Experiment Videos

Last Updated: Jun 25, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

Transfusion Medicine
Infectious Disease Epidemiology
Public Health

Background:

Transfusion-transmitted infections (TTI) remain a primary concern in blood transfusion safety.
Epidemiological studies have driven the development of screening assays for viral pathogens.

Purpose of the Study:

To review advances in blood transfusion safety, focusing on TTI prevention.
To highlight the evolution of screening methods and emerging safety challenges.

Main Methods:

Review of epidemiological studies on TTI.
Description of immunoassays and nucleic acid tests (NAT) for pathogen detection.
Discussion of bacterial contamination and pathogen inactivation technologies.

Main Results:

Immunoassays and NAT have significantly reduced the transmission risk of HBV, HCV, HIV-1/2, and HTLV-I/II.
Nucleic acid tests (NAT) effectively reduce the risk of "window period" infections.
Bacterial contamination, particularly in platelet concentrates, is an emerging safety concern.

Conclusions:

Continued advancements in screening, pathogen inactivation, and hemovigilance are crucial for enhancing blood transfusion safety.
Harmonization of practices and ongoing surveillance are essential for minimizing infectious risks.
Future strategies aim to mitigate risks from both known and emerging infectious agents.