Related Experiment Video
Updated: Jun 25, 2026
04:09
Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes
1Inserm U697, Paris, France.
Diabetes & Metabolism
|February 24, 2009
Summary
Mesenchymal stem cells (MSCs) show promise for treating type 1 diabetes by potentially generating insulin-producing cells. Their immunomodulatory effects may offer a new therapeutic avenue for autoimmune diseases.
Area of Science:
- Immunology
- Endocrinology
- Regenerative Medicine
Background:
- Type 1 diabetes involves autoimmune destruction of pancreatic beta cells, leading to difficult metabolic control with insulin therapy.
- Current treatments like insulin replacement have limitations, and organ transplantation faces donor scarcity and complications.
Purpose of the Study:
- To review the immunomodulatory effects of mesenchymal stem cells (MSCs).
- To present evidence on the therapeutic potential of MSC transplantation for diabetes.
Main Methods:
- Review of experimental evidence on MSCs and their role in diabetes.
- Characterization of MSC immunomodulatory properties.
Main Results:
- MSCs possess low immunogenic potential and modulate immune responses.
- Experimental data suggests MSCs could be a source for insulin-producing cells.
Conclusions:
- MSC-based stem cell therapy is an attractive possibility for generating insulin-producing cells.
- MSC transplantation holds potential as a therapeutic strategy for type 1 diabetes.
Related Concept Videos
01:19Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
01:21Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
01:22iPS Cell Differentiation
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
01:17Stem Cell Culture
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
01:23Tissue Renewal without Stem Cells
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
01:13Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...