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Related Experiment Video

Updated: Jun 25, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Klotho and aging.

Makoto Kuro-o1

  • 1Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd., Dallas, TX 75390-9072, USA. makoto.kuro-o@utsouthwestern.edu

Biochimica Et Biophysica Acta
|February 24, 2009
PubMed
Summary
This summary is machine-generated.

The klotho gene is vital for phosphate balance and aging. Its protein, in both membrane-bound and secreted forms, influences multiple biological processes, potentially linking phosphate metabolism to aging.

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Last Updated: Jun 25, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Area of Science:

  • Biochemistry
  • Genetics
  • Aging Research

Background:

  • The klotho gene encodes a transmembrane protein crucial for FGF23 signaling.
  • FGF23 is a hormone regulating phosphate balance.
  • Klotho and FGF23 are implicated in aging processes.

Purpose of the Study:

  • To investigate the distinct functions of transmembrane and secreted Klotho protein.
  • To explore the link between Klotho, phosphate metabolism, and aging.

Main Methods:

  • Analysis of klotho and Fgf23 gene expression.
  • Studies on protein complex formation with FGF receptors.
  • Investigation of secreted Klotho protein's enzymatic and signaling activities.

Main Results:

  • Klotho acts as an obligatory co-receptor for FGF23, regulating phosphate balance.
  • Defects in Klotho or Fgf23 cause phosphate retention and premature aging in mice.
  • Secreted Klotho exhibits sialidase activity, modulating cell surface glycans and ion channel/growth factor activity.
  • Secreted Klotho also confers protection against oxidative stress.

Conclusions:

  • Transmembrane and secreted Klotho possess distinct functions.
  • These dual roles of Klotho protein significantly impact aging processes in mammals.
  • Klotho represents a potential therapeutic target for aging and metabolic disorders.