Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Novel Hawai'i and Pacific Island circulating clusters of <i>Mycobacterium intracellulare</i> subsp. <i>chimaera</i>.

Applied and environmental microbiology·2026

Same author

The effect of flexor tendon adhesions on finger range of motion.

Hand surgery & rehabilitation·2026

Same author

Revision older adult idiopathic scoliosis patients show less improvement in self-image scores than primary patients following posterior spinal fusion.

Spine deformity·2026

Same author

Pathogen Reduction of Transfused Blood Components-The End of the Beginning Rather than the Beginning of the End.

Pathogens (Basel, Switzerland)·2026

Same author

Soft Tissue Violation Following Intramedullary Screw Fixation of Fractures in the Thumb: A Cadaveric Study.

The Journal of hand surgery·2026

Same author

United Global Advocacy Drives Updates to World Health Organization Essential Medicines List.

Haemophilia : the official journal of the World Federation of Hemophilia·2026

Same journal

Conformational dynamics of pneumococcal polysaccharide conjugates drive UV-vis quantification errors and a strategy to enable UV-vis spectrophotometer quantification.

Biologicals : journal of the International Association of Biological Standardization·2026

Same journal

Refining the regulatory and ethics context of controlled human infection models - a stakeholder meeting report.

Biologicals : journal of the International Association of Biological Standardization·2026

Same journal

Longevity of humoral response in recipients of rabies pre-exposure prophylactic vaccination with Abhayrab®.

Biologicals : journal of the International Association of Biological Standardization·2026

Same journal

Collaborative studies to establish WHO International Reference Reagents for diphtheria and tetanus antitoxin for use in the flocculation test.

Biologicals : journal of the International Association of Biological Standardization·2026

Same journal

Alternative approaches to phase III clinical trials for vaccine efficacy and licensure: the role of real-world evidence - a meeting report.

Biologicals : journal of the International Association of Biological Standardization·2026

Same journal

Leveraging analytical and bioprocess platforms for biological product development and commercialization - A meeting report.

Biologicals : journal of the International Association of Biological Standardization·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

An Optimized Mouse Embryonic Stem Cell Based Reverse Poly-Transfection Technique for Rapid Exploration of Nucleic Acid Ratios

An Optimized Mouse Embryonic Stem Cell Based Reverse Poly-Transfection Technique for Rapid Exploration of Nucleic Acid Ratios

Published on: December 8, 2023

Stem cell and cellular therapy developments.

Michael Strong¹, Albert Farrugia, Paolo Rebulla

¹Northwest Tissue Center, Puget Sound Blood Center, USA. dmichaelstrong@mac.com

Biologicals : Journal of the International Association of Biological Standardization

|February 24, 2009

Summary

This summary is machine-generated.

Advancements in stem cell research are driving the development of cellular therapies. This article reviews clinical translation requirements and presents a case study of a GMP-compliant cellular therapy production site.

More Related Videos

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

Related Experiment Videos

Last Updated: Jun 25, 2026

An Optimized Mouse Embryonic Stem Cell Based Reverse Poly-Transfection Technique for Rapid Exploration of Nucleic Acid Ratios

An Optimized Mouse Embryonic Stem Cell Based Reverse Poly-Transfection Technique for Rapid Exploration of Nucleic Acid Ratios

Published on: December 8, 2023

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

Area of Science:

Regenerative Medicine
Stem Cell Biology
Clinical Translation

Background:

Recent stem cell discoveries fuel novel clinical procedures termed 'cellular therapy'.
Translating laboratory findings into clinical practice necessitates rigorous evaluation of numerous factors.
Key considerations include ethical appropriateness, informed consent, cell sourcing, processing, storage, adverse event management, cost-benefit analysis, and regulatory oversight.

Purpose of the Study:

To describe national and international developments in the clinical distribution of cells and tissues.
To provide an example of implementing a cellular therapy production site adhering to Good Manufacturing Practices (GMPs).

Main Methods:

Review of recent national and international regulatory and developmental advancements.
Case study detailing the establishment of a GMP-compliant cellular therapy production facility within a European university hospital.

Main Results:

Summarizes current trends in cellular therapy distribution and regulatory landscapes.
Demonstrates a practical model for a GMP-compliant production site, addressing critical operational aspects.

Conclusions:

Successful clinical translation of cellular therapies requires meticulous attention to regulatory, ethical, and operational details.
The implementation of GMP-compliant facilities is crucial for ensuring the safety and efficacy of cellular products for clinical use.