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The external iliac artery transitions out of the body cavity, entering the femoral region of the lower leg, and is renamed the femoral artery at the point where it traverses the body wall. This artery is responsible for the distribution of blood to the thigh's deep muscles and the skin's ventral and lateral regions, achieved through several minor branches and the lateral deep femoral artery, which also spawns a lateral circumflex artery. The knee area receives blood from the genicular artery,...

Abdominal Aorta

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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

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Related Experiment Video

Updated: Jun 25, 2026

Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice

Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice

Published on: January 25, 2022

The persistent sciatic artery.

I M van Hooft¹, C J Zeebregts, S M M van Sterkenburg

¹Alysis Zorggroep, Location Rijnstate, Department of Surgery, Division of Vascular Surgery, Wagnerlaan 55, 6815 AD Arnhem, The Netherlands.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery

|February 24, 2009

Summary

Persistent sciatic artery (PSA) is a rare vascular anomaly. This condition frequently causes complications like aneurysms and ischemia, sometimes necessitating amputation.

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Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

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Last Updated: Jun 25, 2026

Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice

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Published on: January 25, 2022

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

Area of Science:

Vascular Surgery
Embryology
Medical Genetics

Background:

Persistent sciatic artery (PSA) is a rare congenital vascular anomaly, occurring in 0.03-0.06% of the population.
It arises from the incomplete regression of the embryonic sciatic artery.
This condition can lead to significant clinical complications if not properly managed.

Purpose of the Study:

To systematically review and analyze the clinical presentation and outcomes of patients with persistent sciatic artery.
To understand the prevalence, associated pathologies, and treatment strategies for PSA.

Main Methods:

A comprehensive systematic review of all published cases of PSA from 1964 to 2007.
Inclusion criteria focused on studies describing clinical details and outcomes of PSA.

Main Results:

159 PSAs in 122 patients were analyzed, with a mean age of discovery at 57 years.
80% of patients presented with symptoms such as claudication, ischemia, or neurological deficits.
Complications included aneurysms (48%), stenosis (7%), and occlusions (9%), with 8% requiring amputation.

Conclusions:

Persistent sciatic artery is a rare condition with a high rate of serious complications, including limb ischemia and the need for amputation.
Further research is needed to establish optimal follow-up and management strategies for PSA.