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Related Experiment Video

Updated: Jun 25, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
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Postinfarction ventricular septal defects: towards a new treatment algorithm?

Simon Maltais1, Reda Ibrahim, Arsène-Joseph Basmadjian

  • 1Cardiac Surgery, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.

The Annals of Thoracic Surgery
|February 24, 2009
PubMed
Summary
This summary is machine-generated.

Early treatment of postinfarction ventricular septal defects (VSD) with surgery or percutaneous closure has high mortality. Timely intervention is crucial for survival, with residual VSD and diagnosis-to-treatment delays as key mortality predictors.

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Published on: April 17, 2021

Area of Science:

  • Cardiology
  • Cardiovascular Surgery
  • Interventional Cardiology

Background:

  • Postinfarction ventricular septal defects (VSD) are a rare but serious complication of myocardial infarction.
  • Early intervention is critical due to high associated morbidity and mortality.

Purpose of the Study:

  • To review the experience with early surgical and percutaneous closure of postinfarction VSD.
  • To identify predictors of mortality in patients with postinfarction VSD.

Main Methods:

  • A retrospective review of 51 patients with postinfarction VSD treated between May 1995 and November 2007.
  • Patients were treated with either surgical closure (39 patients) or percutaneous closure (12 patients).

Main Results:

  • Overall early mortality was 33%.
  • Patients often presented in systemic shock (50%) and required intraaortic balloon pump support (88%).
  • Residual VSD, time from infarction to VSD diagnosis, and time from VSD diagnosis to treatment were significant predictors of mortality. Percutaneous closure had a 42% 30-day mortality.

Conclusions:

  • Small to medium VSDs can be treated with a ventricular septal occluder.
  • Percutaneous closure can stabilize patients, allowing for myocardial healing and facilitating delayed surgical correction.
  • Despite treatment advancements, postinfarction VSD remains associated with high mortality.