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Updated: Jun 25, 2026

In Vivo Confocal Microscopy: A Standard Operating Procedure for the Detection of Demodex Mites at the Eyelid Margin
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Demodicosis: a clinicopathological study.

Chao-Kai Hsu1, Mark Ming-Long Hsu, Julia Yu-Yun Lee

  • 1Department of Dermatology, College of Medicine, University Hospital, Tainan, Taiwan.

Journal of the American Academy of Dermatology
|February 24, 2009
PubMed
Summary
This summary is machine-generated.

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Demodicosis, an overgrowth of Demodex mites, often mimics rosacea and perioral dermatitis. Diagnosis requires skin examination, and treatment can resolve these recalcitrant facial eruptions.

Area of Science:

  • Dermatology
  • Parasitology
  • Microbiology

Background:

  • Demodex mites are common skin commensals.
  • Demodicosis is linked to various facial skin conditions.
  • This study focuses on Taiwanese patients.

Purpose of the Study:

  • To characterize clinicopathological findings of demodicosis.
  • To evaluate treatment responses in demodicosis patients.
  • To understand demodicosis spectrum in Taiwan.

Main Methods:

  • Retrospective review of 34 diagnosed demodicosis cases.
  • Inclusion of 15 cases with positive diagnostic tests and lesion resolution.
  • Analysis of clinical presentation, histopathology, and treatment outcomes.

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Main Results:

  • Common presentations included rosacea-like (n=8) and perioral dermatitis-like (n=5) eruptions.
  • Histopathology showed perifollicular inflammation, excess mites, and pustules.
  • Skin lesions resolved with treatments like metronidazole and gamma benzene hexachloride.

Conclusions:

  • Demodicosis is a crucial differential diagnosis for persistent facial rashes.
  • Diagnostic methods include KOH examination, skin surface biopsy, and skin biopsy.
  • Early diagnosis and treatment are key for managing demodicosis.